Chlormadinone

Chlormadinone

Systematic (IUPAC) name
(9S,14S,17R)-17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	1961-77-9
ATC code	G03DB06
PubChem	CID 16065
ChemSpider	4447590
UNII	SDS4N642GG^Y
KEGG	D07670
Chemical data
Formula	C₂₁H₂₇Cl O₃
Mol. mass	362.89 g/mol
SMILES	eMolecules & PubChem

Chlormadinone (INN) is a progestagen.

Synthesis

Bruckner, K.; Hampel, B.; Johnson, V.; Chem. Ber. 1961, 94, 1225.

Estrogens and progestogens (G03C-D, L02)

Agonist

1st	Norpregnene (Norethisterone^#/Norethisterone acetate • Ethynodiol diacetate)

2nd	Norpregnene (Levonorgestrel^#/Norgestrel/Norelgestromin)

3rd	19-nortestosterone (Desogestrel/Etonogestrel • Gestodene • Norgestimate)

4th	Androstene (Drospirenone) • 19-norprogesterone (Nomegestrol • Promegestone • Trimegestone) • 19-nortestosterone (Dienogest)

17-OH	Chlormadinone • Cyproterone • Medroxyprogesterone/Medroxyprogesterone 17-acetate^# • Megestrol

Other/ ungrouped	Pregnenedione (Gestonorone) • Pregnene (Ethisterone) • Pregnadiene (Medrogestone • Melengestrol) • Norpregnane (Norgestrienone) • Lynestrenol • Norethynodrel • Tibolone • Dydrogesterone • Quingestanol

Agonist

Steroidal	Diosgenin • Estradiol (Ethinylestradiol^#/Mestranol • Estradiol 17 beta-cypionate^# • Polyestradiol phosphate) • Estrone (Estrone sulfate) • Estriol • Promestriene • Equilenin • Equilin

Nonsteroidal	Chlorotrianisene • Dienestrol • Fosfestrol • Diethylstilbestrol • Zeranol

pure antagonist: Fulvestrant

M: ♀ FRS

anat/phys/devp

noco/cong/npls, sysi/epon

proc/asst, drug (G1/G2B/G3CD)